Prevention of Future Deaths reports · 2021

Alex Shaw

Regulation 28 report to prevent future deaths, reference 2021-0141, written 7 May 2021. A coroner writes one of these when an inquest reveals a risk that could cause further deaths unless something changes.

Date of report7 May 2021
Reference2021-0141
DeceasedAlex Shaw
CoronerSarah Murphy
Coroner areaStoke-on-Trent & North Staffordshire Coroner’s Court
CategoryHospital Death (Clinical Procedures and medical management) related deaths · Child Death (from 2015)
Organisation namedUniversity Hospitals of North Midlands NHS Trust
Sourcejudiciary.uk record · original PDF
Responses published2

The report

Text extracted from the PDF text layer. Reproduced verbatim, including the scan's own layout.

REGULATION 28 REPORT TO PREVENT FUTURE DEATHS 

THIS REPORT IS BEING SENT TO:   

1)  Chief Executive of the Royal Stoke University Hospital   
2)  Chief Executive of Birmingham Children’s Hospital. 

1 

CORONER 

I am Sarah Murphy HM Assistant Coroner for Stoke-on-Trent & North Staffordshire Coroner's Court 

2 

CORONER’S LEGAL POWERS 

I make this report under paragraph 7, Schedule 5, of the Coroners and Justice Act 2009 and regulations 
28 and 29 of the Coroners (Investigations) Regulations 2013. 
http://www.legislation.gov.uk/ukpga/2009/25/schedule/5/paragraph/7 
http://www.legislation.gov.uk/uksi/2013/1629/part/7/made 

3 

INVESTIGATION and INQUEST 

On 02/11/2018 I commenced an investigation into the death of Alex Louise Shaw, aged 12. The 
investigation concluded at the end of the inquest on 29th April 2021.  

The conclusion of the inquest was that death was due to complications of therapy for methylmalonic 
aciduria.  

4 

CIRCUMSTANCES OF THE DEATH 

Alex Shaw had a medical history of Methylmalonic Acidemia and chronic kidney insufficiency.   She was 
under the care of the Birmingham Children's Hospital. On the 19th October 2018, she presented to the 
Children's  Assessment  Unit  of  the  Royal  Stoke  University  Hospital,  Stoke-on-Trent  with  a  three  day 
history of vomiting. She was found to be dehydrated and suffering from mild metabolic acidosis. She was 
provisionally  diagnosed  with  gastritis  or  gastroenteritis  and  treated  for  the  metabolic  acidosis  with 
intravenous fluids. A loading dose of carnitine was not administered.  

She  was  admitted  to  the  children's  paediatric  ward.  The  metabolic  consultant  from  the  Birmingham 
Children's Hospital was consulted and in agreement with the management plan and they were contacted 
throughout  her  admission.  Alex  was  on  regular  medications  for  the  management  of  her  condition  but 
they were not immediately written on the drugs charts on the Children's Assessment Unit which resulted 
in 3 missed doses of oral carnitine and a dose of Allopurinol. This did not contribute to her death.  

On  Sunday  21st  October,  her  lactate  level  increased  and  advice  was  sought  from  the  metabolic 
consultant.    Her  heart  rate  was  stable  but  she  continued  to  vomit.  She  commenced  intravenous 
bicarbonate  at  4.00pm  and  Intravenous  carnitine  at  5.30pm  the  same  day.  At  6.00pm  her  heart  rate 
began  to  rise.    She  was  placed  on  a  heart  rate  monitor  but  the  time  of  this  was  not  noted  and  the 
metabolic consultant had not been informed. Blood gases at 10.15pm showed that her acid level had not 
responded. There was a discrepancy as to the timing, but the metabolic consultant had been informed of 
the blood gas results between 10.30pm and 11.11pm and told that there was a stable heart rate when it 
was raised. Advice was given to administer a half correction of bicarbonate infusion, to increase the dose 
of  the  intravenous  sodium  bicarbonate  injection  from  8mmol  to  15mmol  four  times  a  day,  to  repeat 
blood  gas  after  the  bicarbonate  correction  had  finished  and  to  give  a  fluid  bolus  if  haemodynamically 
unstable. 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 After a medical review, Alex was found to be haemodynamically unstable and still vomiting. At 11.00pm, 
a  nasogastric  tube  was  inserted  which  drained  160ml  of  greenish  coloured  aspirate  .A  fluid  bolus  was 
administered at 11.30pm before a CT scan. Before the fluid bolus was given, Alex's chest was examined 
and  found  to  be  clear,  and  there  was  no  evidence  of  stress  to  her  heart.  Intravenous  carnitine  was 
administered  at  midnight  and  around  the  same  time;  the  management  plan  was  discussed  with  the 
Intensive  Care  Consultant  who  was  informed  that  Alex  had  been  transferred  to  the  High  Dependency 
Unit. Consideration was given for transfer to intensive care unit but it was not considered necessary.  A 
CT  scan  was  completed  at  1.00am  on  Monday  22nd  October  2018  which  did  not  find  any  bowel 
obstruction.  The  cause  of  the bilious  vomiting  was  not identified  during  the hospital  admission.  Whilst 
Alex was breathing faster, there was no evidence that she was suffering from a lack of oxygen at the time 
of the CT scan. After the CT scan, she was started on a half correction of sodium bicarbonate plus 120% 
of normal fluid correction.  

After  2.30am  on  Monday  22nd  October,  her  oxygen  levels  had  worsened  and  following  review  by  the 
Intensive  Care  Registrar,  supplemental  oxygen  was  delivered  by  a  mask.  Elective  ventilation  was  not 
considered necessary prior to 2.30am on Monday 22nd October. A chest x ray was completed and she 
was  diagnosed  with  pulmonary  oedema.  The  evidence  was  not  able  to  determine  the  cause  of  the 
pulmonary  oedema.  Intravenous  fluids  were  stopped  apart  from  the  intravenous  bicarbonate  and  she 
was treated with intravenous furosemide. A decision was made to intubate when she could not manage 
with oxygen masks alone. The intensive care consultant and anaesthetist were preparing to intubate but 
her  heart  rate  dropped.  Cardiac  pulmonary  resuscitation  was  started  at  4.08am  and  a  pulse  was 
regained.    She  was  intubated  but  her  heart  immediately  stopped.    Despite  chest  compression  and 
emergency medication, it was not possible to re-start her heart.  The metabolic consultant was contacted 
when Alex went into cardiac arrest for the second time. Cardiopulmonary resuscitation was stopped at 
4.58 hours on the 22nd October 2018 when Alex passed away. A post mortem examination found that 
death was not due to metabolic acidosis and that there was fluid overload around the lungs, heart and 
abdominal cavity. The build-up of fluid in and around the lungs resulted in a failure to breathe and led to 
death.  The  cause  of  the  bilious  vomiting  was  not  identified  at  post  mortem.  The  free  carnitine  on  the 
post mortem dried blood spot was 450 umol/L which was within the normal range.  

The cause of death was: 
1a) Fluid overload due to complications of therapy for methylmalonic aciduria and dehydration. 
1b) - 
1c) - 
2) Chronic Kidney Failure 

5 

CORONER’S CONCERNS 

During the course of the inquest the evidence revealed matters giving rise to concern. In my opinion 
there is a risk that future deaths will occur unless action is taken. In the circumstances it is my statutory 
duty to report to you. 

The MATTERS OF CONCERN are as follows.  –  

[BRIEF SUMMARY OF MATTERS OF CONCERN] 

(1)  There  was  poor  communication  of  the  patient’s  clinical  condition/observations  between  the 
Registrar at the Royal Stoke University Hospital and the Consultant at the Birmingham Children’s 
Hospital  when  advice  was  sought  by  telephone.  There  was  also  poor  documentation  of  the 
contents of the information that had been provided during that conversation and the timing of 
when the call was made. The evidence of the Consultant at the Birmingham Children’s Hospital 
was  that  her  advice  would  have  been  different  if  she  had  been  made  aware  of  the  patient’s 
rising heart rate. 

(2)  The evidence also revealed that it was a “judgment call” when the clinician felt that a dialogue 

between clinician’s at a different hospital needed to be documented. 

(3)  Consideration should be given as to how a patient’s observations are communicated to 

clinician’s between the University Hospital and the Birmingham Children’s Hospital, the time, 
content, advice and documentation of the conversations. 

 
 
 
 
 
 
 
 
 
 6 

ACTION SHOULD BE TAKEN 

In my opinion action should be taken to prevent future deaths and I believe you have the power to take 
such action.  

7 

YOUR RESPONSE 

You are under a duty to respond to this report within 56 days of the date of this report, namely by 5th 
July 2021. I, the coroner, may extend the period. 

Your response must contain details of action taken or proposed to be taken, setting out the timetable for 
action. Otherwise you must explain why no action is proposed. 

8 

COPIES and PUBLICATION 

I have sent a copy of my report to the Chief Coroner and to the following Interested Persons: 

 
  Dickson’s Solicitors (Solicitor for the family). 

 (Parents of the deceased). 

I am also under a duty to send the Chief Coroner a copy of your response and all interested persons who 
in my opinion should receive it. 

I may also send a copy of your response to any other person who I believe may find it useful or of 
interest. 

The Chief Coroner may publish either or both in a complete or redacted or summary form. He may send a 
copy of this report to any person who he believes may find it useful or of interest.  

You may make representations to me, the coroner, at the time of your response, about the release or the 
publication of your response. 

9 

07/05/2021 

Signature_________

________________ 

Sarah Murphy HM Assistant Coroner Stoke-on-Trent & North Staffordshire Coroner's Court

Responses

2 responses published against this report on judiciary.uk. A response is a body's written reply to the coroner's concerns; publication is at the discretion of the Chief Coroner's office, so an absent response does not mean nobody replied.

Response from Birmingham Womens and Childrens Nhsft (PDF)
Chief Medical Officer 
Executive Team 
Birmingham Women’s and Children’s NHSFT 
Steelhouse Lane 
Birmingham 
B4 6NH 

www.bwc.nhs.uk 

Ms Sarah Murphy 
Assistant Coroner for Stoke on Trent and North Staffordshire 
547 Hartshill Road 
Hartshill  
ST4 6HF 

28 June 2021 

Dear Ms Murphy  

Re: Alex Louise Shaw; Regulation 28 Report to Prevent Future Deaths 

I write in response to your Regulation 28 Report issued to Birmingham Women’s and Children’s NHS 
Foundation Trust on 7 May 2021, following the inquest into the death of Alex Louise Shaw.  

On behalf of the Trust, I would like to reiterate the sincere condolences given by Dr 

and Dr 

 at the hearing on 2 March 2021.   

The matters of concern you raised in your Report are as follows;  

“(1)  There  was  poor  communication  of  the  patient’s  clinical  condition/observations  between  the 
Registrar  at  the  Royal  Stoke  University  Hospital  and  the  Consultant  at  the  Birmingham  Children’s 
Hospital when advice was sought by telephone. There was also poor documentation of the contents 
of the information that had been provided during that conversation and the timing of when the call was 
made.  The  evidence  of  the  Consultant  at  the  Birmingham  Children’s  Hospital  was  that  her  advice 
would have been different if she had been made aware of the patient’s rising heart rate.  
(2)  The  evidence  also  revealed  that  it  was  a  “judgment  call”  when  the  clinician  felt  that  a  dialogue 
between clinician’s at a different hospital needed to be documented.  
(3) Consideration should be given as to how a patient’s observations are communicated to clinician’s 
between  the  University  Hospital  and  the  Birmingham  Children’s  Hospital,  the  time,  content,  advice 
and documentation of the conversations.”  

We do not currently have a Trust wide process or system for logging discussions with other centres or 
referrals for advice we may receive from other agencies. We are therefore reliant on our colleagues’ 
documentation and the transfer of that to the patient record.  

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 It is acknowledged that this will result in inconsistencies in practice and as a result, the Trust’s Chief 
Clinical Information Officer (CCIO) as Associate Chief Medical Officer for IT and Information, together 
with  the  Trust’s  Chief  Technology  Officer  and  Data  Protection  Officer for  the  Trust  are  scoping  how 
the  recording  of  information  pertaining  to  patients  who  are  not  on  our  premises  but  who  need 
specialist clinical advice can be improved.  

Norse 

We have a limited deployment of an electronic product called Norse. This facilitates a typed ongoing 
conversation  between  a  clinician’s  at  this  Trust  and  at  another  centre. This  system  includes  some 
features including an ability for our staff to request baseline information at the start of the conversation 
and include other  clinicians as  appropriate in the conversation.  At conclusion of the discussion, it is 
then possible to retain the detail of the dialogue. 

I  understand  from  my  senior  IT  colleagues  that  they  are  currently  working  with  the  supplier  of  this 
system  to  support  transition  to  the  most  recent  version  of  it  to  include  its  additional  and  most  up  to 
date  features.  The  long  term  plan  is  to  have  the  Norse  system  rolled  out  into  a  number  of  clinical 
services in the trust but as yet there is not a defined timetable for this. The roll out of this system will 
provide  a  more  rigid  requirement  in  respect  of  the  information  to  be  documented,  ensuring  that 
patient’s observations are communicated between clinicians at this Trust and colleague’s from other 
centres.  

PERPH   

Clinicians at our Birmingham Children’s site will sometimes use some of the functionality in a system 
which the Trust already has the use of, PEPRH. This is a handover system and provides a facility to 
record  some  advice  on  an  ongoing  basis.  The  use  of  this  system  is  very  limited,  and  is  likely  to  be 
superseded by the implementation of the Norse system.  

PEPR   

PEPR is an electronic record keeping system used within this Trust at the Birmingham Children’s site. 
All  PEPR  users  have  the  ability  to  upload  any  document  against  any  patient  record.   This  is  mostly 
used for retaining incoming correspondence, however, theoretically a clinician could, on giving advice, 
write  themselves  an  email  –  and  perhaps  copy  this  to  the  referring  clinician  –  which  could  then  be 
(manually) uploaded to PEPR.  

We  will  remind  clinicians  of  the  need  to  keep  contemporaneous  notes  about  advice  given  about 
advice given to district general hospitals by placing a note in patient’s record.  

I hope this letter assures you that the concerns you raised  have been acknowledged and that efforts 
are being made to improve record keeping in respect of professional discussions between BWC staff 
and other centres. 

Yours sincerely 

Chief Medical Officer 
Birmingham Women’s and Children’s NHSFT
Response from Royal Stoke University Hospital (PDF)
16 June 2021 

Ms Murphy 
H M Assistant Coroner  
547 Hartshill Road 
Stoke on Trent 
ST4 6HF 

Dear Ms Murphy   

Royal Stoke University Hospital 
Executive Suite 
Springfield 
Newcastle Road 
Stoke-on-Trent 
Staffordshire 
ST4 6QG 

Inquest Touching the Death of Alex Shaw  

Further to your letter dated 7 May 2021, I am pleased to provide the following response to address the 
concerns that you raised at the inquest touching the death of Alex Shaw. 

You raised a number of matters of concern to be addressed by both this Trust and Birmingham Children’s 
Hospital. Set out below are the actions undertaken by University Hospitals of North Midlands NHS Trust in 
response to the issues highlighted. 

1)  There  was  poor  communication  of  the  patient’s  clinical  condition/observations  between  the 
Registrar at the Royal Stoke University Hospital and the Consultant at the Birmingham Children’s 
Hospital  when  advice  was  sought  by  telephone.  There  was  also  poor  documentation  of  the 
contents of the information that had been provided during that conversation and the timing of when 
the call was made. The evidence of the Consultant at the Birmingham Children’s Hospital was that 
her advice would have been different if she had been made aware of the patient’s rising heart rate.  

2)  The  evidence  also  revealed  that  it  was  a  “judgment  call”  when  the  clinician  felt  that  a  dialogue 

between clinician’s at a different hospital needed to be documented. 

3)  Consideration should be given as to how a patient’s observations are communicated to clinician’s 
between the University Hospital and the Birmingham Children’s Hospital, the time, content, advice 
and documentation of the conversations.  

Action Taken 
As a result of the concerns raised, the following action has been taken: 

1)  The  paediatric  team  are  in the  process  of  developing  a facility  on  the Trust  electronic  Iportal 
System  which  will  provide  a  structured  note  ‘Paediatric  Advice  Proforma’  to  aid  electronic 
documentation of conversations between hospitals when seeking advice on patient care; this 
will  include  prompts  for  important  discussion  points  and  will  have  mandatory  fields  for  vital 
signs (such as heart rate, BP etc.) which will ensure that the clinician includes such information 
in conversation. Matters are currently being developed with the IT team and we hope to have a 
solution by September 2021. 

Page 1 of 1 

 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 2)  In response to point  2,  the  paediatric team  are also  aiming  to  develop  a Standard  Operating 
Procedure (SoP) which will also refer to the need to compete the Paediatric Advice Proforma. 
This  SoP  will  be  relevant  to  discussions  between  hospital  Trusts  and  will  follow  on  from  the 
work undertaken as per point 1. It will require clinicians to document all discussions.  

3)  As discussed in point 1 above, the development of the ‘Paediatric Advice Proforma’ will prompt 
clinicians to input time of conversation, content of the request, information shared and advice 
given / received.  

In  addition  to  the  above  direct  actions,  I  am  also  very  pleased  to  share  that  Staffordshire  Children’s 
Hospital  at  Royal  Stoke  has  recently  appointed  a  named  Consultant  who  will  be  responsible  for  the 
management of all children with metabolic disease.  

I sincerely hope that the above information provides you with assurance that the University Hospitals of 
North Midlands NHS Trust has taken the matters arising from the inquest touching upon the death of Alex 
Shaw seriously.  

The  Trust  strives  to  provide  a  high  standard  of  care  to  all  patients  and  I  am  grateful  to  you  for  raising 
these concerns on this occasion.  

Should you wish to discuss any aspect of this report further, please do not hesitate to contact me. 

Yours sincerely 

CHIEF EXECUTIVE  

Enclosure: Action Plan  

Page 2 of 1

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