Prevention of Future Deaths reports · 2019

Stuart Clarke

Regulation 28 report to prevent future deaths, reference 2019-0366, written 6 Nov 2019. A coroner writes one of these when an inquest reveals a risk that could cause further deaths unless something changes.

Date of report6 Nov 2019
Reference2019-0366
DeceasedStuart Clarke
CoronerRachel Galloway
Coroner areaManchester City
CategoryHospital Death (Clinical Procedures and medical management) related deaths
Organisation namedManchester University NHS Foundation Trust
Sourcejudiciary.uk record · original PDF
Responses published4

The report

Text extracted from the PDF text layer. Reproduced verbatim, including the scan's own layout.

REGULATION 28:  REPORT TO PREVENT FUTURE DEATHS  

REGULATION 28 REPORT TO PREVENT FUTURE DEATHS 

THIS REPORT IS BEING SENT TO:   

(1)  NHS England and NHS Improvement  
(2)  National Institute for Health and Care Excellence (NICE) 
(3)  Department of Health and Social Care 
(4)  British Cardiovascular Intervention Society 

1 

CORONER 

I am, Rachel Galloway, Assistant Coroner for the Coroner Area of Manchester City. 

2 

CORONER’S LEGAL POWERS 

I make this report under paragraph 7, Schedule 5, of the Coroners and Justice Act 2009 
and regulations 28 and 29 of the Coroners (Investigations) Regulations 2013 

3 

INVESTIGATION and INQUEST 

On the 2nd July 2019 an investigation was commenced into the death of Stuart Clarke, 
aged 82 years, born on the 15th October 1936.  

The investigation concluded following the inquest on the 22nd October 2019.     

The Medical Cause of Death was:  

1a Pulmonary Oedema  
1b Left Ventricular Dysfunction  

II Complications of Aortic Valve Procedure, Coronary Artery Disease and Hypertension.   

The conclusion at the inquest was: 

Narrative Conclusion:  Stuart Clarke died as a consequence of naturally occurring 
disease, exacerbated by complications arising out of an aortic valve procedure.  

4 

CIRCUMSTANCES OF THE DEATH 

1. 

In February 2018, Stuart Clarke presented at his GP with symptoms of 
breathlessness.  However, it was not until the 25th June 2019 (16 months later) 
that Mr Clarke finally underwent necessary Transcatheter Aortic Valve 
Implantation (TAVI) at Wythenshawe Hospital. 

2.  Evidence was heard from the Consultant Cardiologist at Wythenshawe Hospital, 
who carried out the TAVI procedure on the 25th June 2019.  She confirmed that 
this overall pathway from onset of symptoms to treatment in Mr Clarke’s case 
was unacceptably long.  In the event, Mr Clarke did not recover following the 
procedure on the 25th June 2019 and his condition declined, leading to his death 
at Wythenshawe Hospital on the 27th June 2019.   

1 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 In evidence, the Consultant Cardiology expressed the view that – had the 
procedure been carried out in a timelier manner – the outcome might have been 
different for Mr Clarke.  She could not say if the outcome would have been 
different on the balance of probabilities.   

3.  The Consultant Cardiologist explained that the normal patient journey would 

involve referral by the GP to the local hospital.  In the present case, Mr Clarke 
was referred to Cardiology at Royal Oldham Hospital.  It is then for the local 
hospital (in this instance, Royal Oldham Hospital) to refer to the tertiary centre 
(in this case, Wythenshawe Hospital) for specialist assessment.  Mr Clarke was 
not seen at Wythenshawe Hospital until January 2019.  It then took a further 5 
months for his suitability for TAVI to be confirmed and then for the procedure to 
take place.   

5 

CORONER’S CONCERNS 

During the inquest the evidence revealed matters giving rise to concern.  In my opinion 
there is a risk that future deaths will occur unless action is taken.  In the circumstances it 
is my statutory duty to report to you.   

During the inquest, evidence was heard that:  

By the time that Mr Clarke underwent the TAVI procedure on the 25th June 2019 he had 
deteriorated and was significantly less well than he had been in the months following his 
initial presentation to his GP in February 2018.  During the course of the inquest, I heard 
that steps are being taken at local level to ensure more timely intervention in similar 
cases.  However, I was concerned that there remain no national guidelines for referral 
from primary care to secondary care and/or from secondary care to tertiary care for 
patients with known valve disease.   

6 

ACTION SHOULD BE TAKEN 

In my opinion action should be taken to prevent future deaths and I believe you have the 
power to take such action.  

7 

YOUR RESPONSE 

You are under a duty to respond to this report within 56 days of the date of this report, 
namely by Monday 6th January 2020. I, the assistant coroner, may extend the period. 

Your response must contain details of action taken or proposed to be taken, setting out 
the timetable for action. Otherwise you must explain why no action is proposed. 

8 

COPIES and PUBLICATION 

I have sent a copy of my report to the Chief Coroner and the following Persons:  

 – Wife of Mr Clarke  

(1) 
(2) 
(3)  Medical Director - Manchester University NHS Foundation Trust 
(4)  Medical Director – The Pennine Acute Hospitals NHS Foundation Trust  
(5)  MFT Heart and Lung Clinical Standards Group  

 – Daughter of Mr Clarke  

2 

 
 
 
 
 
 
 
  
 
 
 
 
 
 
 
 
 
 
 I am also under a duty to send the Chief Coroner a copy of your response.  

The Chief Coroner may publish either or both in a complete or redacted or summary 
form. He may send a copy of this report to any person who he believes may find it useful 
or of interest. You may make representations to me, the assistant coroner, at the time of 
your response, about the release or the publication of your response by the Chief 
Coroner. 

9 

Dated         6th November 2019       

Signed:  

Rachel Galloway  
HM Assistant Coroner  

3

Responses

4 responses published against this report on judiciary.uk. A response is a body's written reply to the coroner's concerns; publication is at the discretion of the Chief Coroner's office, so an absent response does not mean nobody replied.

Response from Bcis (PDF)
President 
Prof Adrian Banning 
Department of Cardiology  
John Radcliffe Hospital 
Headington 
Oxford 
OX3 9DU 

Honorary Secretary 

Treasurer 

Department of Cardiology 
Leeds General Infirmary 
Great George Street 
Leeds 
LS1 3EX  

Manchester Heart Centre 
Manchester Royal Infirmary 
Oxford Road 
Manchester 
M13 9WL 

Ms Rachel Galloway 
H.M Assistant Coroner 
H.M Coroner’s Office 
Manchester City Area 
Exchange Floor 
The Royal Exchange 
Cross Street 
Manchester, M2 7EF 

12 December 2019 

Dear Ms Galloway 

Regulation 28 report (re: Stuart Clarke, deceased) 

Thank you for contacting the British Cardiovascular Intervention Society (BCIS) about 
the outcome of this recent inquest. We note that the patient presented with symptoms 
of breathlessness in Feb 2018 and sadly died two days after a TAVI procedure in June 
2019. We agree that this represents a clinically unacceptable delay (18 months) before 
the TAVI procedure was performed. 

Transcatheter Aortic Valve Intervention (TAVI) is a transformative technology which 
is much less invasive than conventional open heart surgery. Large international clinical 
trials have shown that patient outcomes are better than conventional surgery for patients 
who  are  ‘high  risk’  (Euroscore  II  >8%)  or  ‘intermediate  risk’  (Euroscore  II  >4%) 
surgical  candidates. As the evidence base increases it is  likely that  the  use of  TAVI 
internationally will grow. 

Our professional society has published an updated service specification for TAVI this 
year  (enclosed).  In  this  document  we  outline  the  essential  criteria  for  hospitals  to 
provide a high quality TAVI service. These include detailed recommendations about 
training, hospital volumes, length of stay and national data collection. In particular we 
recommend a maximum waiting time of 18 weeks between initial referral and treatment 
and local audit of waiting times. 

BCIS would support the Department of Health and NHS England in moves to ensure 
that there is adequate capacity for TAVI candidates to be seen, investigated and treated 
without undue delay. In addition, we will contact our members to ask them to review 
local referral pathways to expedite treatment and prevent delays. 

c/o BCS, 9 Fitzroy Square, London W1T 5HW / Tel: +44 (0)20 7380 1918 / Email bcis@bcs.com / Web: www.bcis.org.uk 

Company limited by guarantee, registered no 07326046. Registered charity no 1138385 

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  
   
 
 
 
 
 
 
 
 
 
 
 
 Yours sincerely 

Dr Gerald Clesham 
Chairman, Clinical Standards Group, British Cardiovascular Intervention Society 

c/o BCS, 9 Fitzroy Square, London W1T 5HW / Tel: +44 (0)20 7380 1918 / Email bcis@bcs.com / Web: www.bcis.org.uk 

Company limited by guarantee, registered no 07326046. Registered charity no 1138385
Response from Dhsc 1 (PDF)
a6} F le G FE I V E From Edward Argar MP

Departm ent Minister of State for Health
~ 9 MAR 2028 ero

of Health & 39 Victoria Street

SocialCare  __uut Pe. SW1H EU

020 7210 4850

Our Reference: PFD-1196556

Ms Rachel Galloway

HM Assistant Coroner, Manchester City
HM Coroner's Office

Exchange Floor, The Royal Exchange
Cross Street

Manchester M2 7EF nt

5” March 2020

Den Me Gatien,

Thank you for your letter of 5 November 2019 to Matt Hancock about the death of Mr
Stuart Clarke. | am replying as Minister with responsibility for elective care and | am
grateful for the additional time in which to do so.

Firstly, | would like to extend my deepest sympathies to Mr Clarke’s family and loved ones.
| understand how distressing it is to lose a loved one and concerns about the timeliness of
the medical treatment Mr Clarke received must be particularly upsetting. We must do all
we can to learn from Mr Clarke’s death to make improvements and prevent future deaths.

You issued your report to NHS England and NHS Improvement and the National Institute
for Health and Care Excellence (NICE). You will therefore be aware from their responses
that existing NICE guidance on chronic heart failure’, issued in 2018, does not specify a
time in which patients with chronic heart failure thought to be caused by heart valve
disease should be seen by a specialist. The timing of any intervention is a matter of
clinical judgement and services should be arranged to support the provision of timely and
appropriate clinical care.

| note that NICE is currently developing a clinical guideline on heart valve disease in adults
and the guideline is expected to cover investigation and management of the condition, as
well as indications for the referral of patients from primary to specialist care. | understand
that the matters of concern in your report about the circumstances of Mr Clarke’s treatment
journey will be made known to those developing the guideline.

The provision of Transcatheter Aortic Valve Implantation (TAVI) services in Greater
Manchester is a matter for the relevant NHS acute trust, with oversight from NHS England
as the commissioner of specialised services. It is for the NHS in Greater Manchester to

1 https:/Awww.nice org.uk/guidance/ng106

work with NHS England to ensure that services meet the healthcare needs of patients with
heart valve disease.

| am advised that the Manchester University NHS Foundation Trust, which is the only NHS
trust in Greater Manchester to provide TAVI, is looking at how it can improve processes to
support quicker diagnosis and treatment for patients with suspected heart valve disease.
In addition, the Greater Manchester Cardiac Network is looking at what more can be done
to support GPs across Greater Manchester to identify and refer patients with heart
problems in good time to the right heart specialist centre.

| hope this response is helpful. Thank you for bringing these concerns to my attention.

EDWARD ARGAR MP
Response from NHS Eng and NHS Imp (PDF)
Professor Stephen Powis 
                                    National Medical Director 
                                                    Skipton House 
                                                 80 London Road 
                                                              SE1 6LH 

 10th February 2020 

Ms Rachel Galloway         
HM Assistant Coroner 
H.M. Coroner’s Office 
Manchester City Area 
Exchange Floor 
The Royal Exchange 
Cross Street 
Manchester 
M2 7EF 

Dear Ms Galloway  

Re: Regulation 28 Report to Prevent Future Deaths – Stuart Clarke, 27 June 
2019 

Thank you for your Regulation 28 Report (hereinafter the ‘report’) dated 05 
November 2019 concerning the death of Mr Stuart Clarke on 27 June 2019.  Firstly, 
I would like to express my deep condolences to Mr Clarke’s family.  

The report notes that the recent inquest concluded that Mr Clarke’s death was a 
consequence of naturally occurring disease, exacerbated by complications arising 
out of an aortic valve procedure.   

Following the inquest, you raised concerns in the report for the consideration of 
NHS England regarding a risk that future deaths will occur unless action is taken. In 
particular you were concerned that there is no national guideline for referral from 
primary care to secondary care, and/or from secondary care to tertiary care, for 
patients with known valve disease.   

In response please note following the very sad death of Mr Clarke, the cardiac 
doctors of the Greater Manchester Cardiac Network have reviewed the case and 
believe that the main issue in Mr Clarke’s care was the delay in his specialised 
treatment.  Currently there are no national targets or guidelines on how quickly a 
patient with a heart condition similar to Mr Clarke’s should be diagnosed and then 
receive the corrective treatment.  However if on the first presentation of symptoms 
Mr Clarke was clinically suitable and eligible for a Transcatheter aortic value 
implantation (TAVI) procedure, the clinicians believe the length of wait was and is 
unacceptable.  

The procedure that Mr Clarke had (TAVI) is only performed at one specialist heart 
centre in Greater Manchester at Manchester Foundation Trust (MFT).  Patients 
who need this procedure are referred into the service through hospital cardiology 
departments. 

MFT has already started looking at how to improve systems between the two 

NHS England and NHS Improvement 

 
 
 
 
 
 
 
 
 
 
 
 
 
    
 
 
 
                                                          
                                                     
 
 
 cardiac centres (Manchester Royal Infirmary and Wythenshawe Hospital) so that 
patients with this heart condition are able to receive a much quicker service. 
The Greater Manchester Cardiac Network, which includes cardiac doctors, nurses 
and other health professionals will now look at how they could support and extend 
the work being done at MFT to improve this heart care pathway so that people 
across GM are better identified by General Practitioners (GPs) and then sent to the 
right heart specialist centre to have the procedure done much quicker than is 
currently the case. 

Thank you for bringing this important patient safety issue to my attention and 
please do not hesitate to contact me should you need any further information. 

Yours sincerely, 

Professor Stephen Powis 
National Medical Director   
NHS England and NHS Improvement  

NHS England and NHS Improvement
Response from Nice (PDF)
Roo) 25 — Fufs,

MICE.

N | C National Institute for 10 Spring Gardens
Health and Care Excellence London
SW1A 2BU
United Kingdom
11 December 2019
+44 (0)300 323 0140
Rachel Galloway iy
HM Assistant Coroner iy G giv
HM Coroner's Office C nid
Manchester City Area 46 dE o>
Exchange floor ones (<1

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Our ref. EH-302753

Dear Ms Galloway,

| write in response to your letter of 5 November 2019, regarding the death of Mr Stuart
Clarke.

We have considered the circumstances surrounding Mr Clarke’s death, and the concern
raised in your report, that there are no national guidelines for referral from primary care to
secondary care and/or from secondary care to tertiary care for patients with known valve
disease

Based on the clinical detail provided, it’s not clear how severe Mr Clarke’s symptoms were or
if any other symptoms were present However, It appears likely that the NICE guideline on
chronic heart failure in adults (NG106) is relevant

This guideline contains the following recommendations regarding the speed of specialist
assessment

1 2 3 Because very high levels of NT-proBNP carry a poor prognosis, refer people with
suspected heart failure and an NT-proBNP level above 2,000 ng/litre (236 pmol/litre)
urgently, to have specialist assessment and transthoracic echocardiography within

2 weeks, [2018]

1 2 4 Refer people with suspected heart failure and an NT-proBNP level between 400 and
2,000 ng/itre (47 to 236 pmol/itre) to have specialist assessment and transthoracic
echocardiography within 6 weeks. [2018]

Where chronic heart failure 1s thought to be due to heart valve disease, we make this
recommendation, but we do not specify a referral time since this would depend on the
severity of the symptoms

www.nice.org.uk | nice@nice.org.uk

1.2 15 Refer people with heart failure caused by valve disease for specialist assessment and
advice regarding follow-up [2003]

Ultimately, we consider the degree of urgency would be a matter for clinical judgement and
will depend on the individual clinical scenario It 1s important that services are organised in
such a way to respond appropriately to clinical scenarios to allow progression through the

pathway in an appropriate and timely way. The organisation of such services would be the
responsiblity of the Trust, with oversight from the specialist commissioner (NHS England).

NICE ts at the early stages of developing a clinical guideline on heart valve disease
presenting in adults: investigation and management One of the issues to be covered by this
guideline are the indications for patient referral from primary care to a specialist

The draft guidance is expected to go out for consultation with stakeholders in November
2020, and we expect to publish our final guideline to the NHS on 20 May 2021

Details of the concerns you have raised have been highlighted to the guideline developers,
so they can consider indicating which factors merit more and less urgent referral, where the
evidence is available

This guideline will also be considering the indications for TAVI, and its clinical effectiveness
and cost effectiveness However, we are unlikely to cover issues relating to the patient
pathway from secondary to tertiary care, as TAVI is commissioned by NHS England (as
outlined within their publication titled ‘Clinical Commissioning Policy Transcatheter Aortic
Valve Implantation (TAVI) For Aortic Stenosis’

Yours sincerely,

Sir Andrew Dillon
Chief Executive

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